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KMID : 0895820050150010099
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Journal of Oriental Rehabilitation Medicine
2005 Volume.15 No. 1 p.99 ~ p.108
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Inhibitory Effect of Acute Pancreatitis in Rats by Patrinia Scabiosaefolia
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Lee Joon-Suk
Jung Sang-Pil
Kil Eun-Young
Lee Su-Kyung
Kwon Young-Dal
Song Yung-Sun
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Abstract
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Objectives: Patrinia scabiosaefolia (PS) has long been used as a remedy for treating infectious diseases in Korea. In the present experiments, the author examined the effects of PS on the cholecystokinin-octapeptide (CCK)-induced acute pancreatitis (AP) in rats.
Methods: Male Wistar rats weighing 200 to 250 g were divided into two groups. Normal untreated group, in treatment with PS group; PS was administered orally, followed by 75 ㎍/㎏ CCK subcutaneously three times, after 1, 3 and 5 h. This whole procedure was repeated for 5 days. In treatment with saline group, the protocol was the same as in treatment group with PS. The author determined the pancreatic weight/body weight ratio, the levels of pancreatic heat shock proteins(HSP)60, HSP72 and the secretion of pro-inflammatory cytokines.
Results and Conclusions: PS was significantly decreased the pancreatic weight/body weight ratio in CCK-induced AP. PS increased HSP60 and HSP72 compared with CCK-induced AP. Additionally, the secretion of tumour necrosis factor(TNF)-α, interleukin(IL)-1β and IL-6 the levels of amylase and lipase were lower than that of saline. These results suggest that PS may has a inhibitory effect against CCK-induced AP.
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KEYWORD
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Patrinia Scabiosaefolia, Acute pancreatitis, TNF-α, IL-1β, IL-6
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